Proteomic advances in salivary diagnostics |
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| Institution: | 1. Istituto di Biochimica e Biochimica Clinica, Facoltà di Medicina, Università Cattolica e Istituto di Chimica del Riconoscimento Molecolare CNR, Roma, Italy;2. Dip. di Medicina dei Sistemi, Unità Operativa di Psichiatria, Univ. di Tor Vergata, Roma, Italy;3. Dip. di Scienze della Vita e dell''Ambiente, Sezione di Biochimica e Biologia Molecolare Università di Cagliari, Italy;4. Dip. di Scienze Sperimentali e Cliniche, Univ. G. D''Annunzio, Chieti, Italy;5. Istituto di Clinica Odontostomatologica, Facoltà di Medicina, Università Cattolica, Roma, Italy;6. Dip. di Scienze Chirurgiche, Sez. Anatomia Patologica, Università di Cagliari, Italy;1. Institute of Agrarian and Environmental Environmental Sciences (ICAAM), University of Évora, Portugal;2. Department of Veterinary Medicine, School of Science and Technology, University of Évora, Portugal;3. Institute of Chemical and Biological Technology (ITQB), New University of Lisbon, Portugal;4. CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal;5. Faculty of Medicine, University of Coimbra, Portugal;6. Clinic for Internal Dieaases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia;7. Department of Biology, School of Science and Technology, University of Évora, Portugal;8. Interlab-UMU, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain;1. Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, People''s Republic of China;2. Joint International Research Centre of Translational and Clinical Research, Beijing, People''s Republic of China;3. Faculty of Dentistry, Oral and Craniofacial Sciences, King''s College London, London, United Kingdom |
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| Abstract: | Saliva is identified as functional equivalent to serum, reflecting the physiological state of the body, as well as hormonal, emotional, nutritional and metabolic alterations. The application of mass spectrometry based approaches has allowed a thorough characterization of the saliva proteome and led to the discovery of putative biomarkers. Several salivary biomarkers have been recently explored as potentially useful screening tools in patients diagnosed with metabolic disorders. In this review, we provide an overview of saliva proteomics studies, with a focus on diabetes, and we explore the evidence for the utility of well identified markers for the diagnosis and monitoring of the disease. Emerging approaches in salivary diagnostics that may significantly advance the field of diabetes research are also highlighted. |
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