Gene-dosage mapping of 30 DNA markers on chromosome 21. |
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| Authors: | J M Delabar Z Chettouh Z Rahmani D Theophile J L Blouin R Bono J Kraus J Barton D Patterson P M Sinet |
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| Affiliation: | URA CNRS 1335, H?pital Necker, Paris, France. |
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| Abstract: | Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined. |
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