The elusive sizer

Size control has been a topic of interest to cell biologists for over a century, but insights into cell size control mechanisms have until recently been relatively sparse. Determining whether cells have a size measurement mechanism and how it might operate has proven difficult. The nucleocytoplasmic ratio is one of the few conserved features of size control but little is know about how it is measured. Models where growth and division can be uncoupled have been underexploited, but have considerable potential for gaining insights into the contribution of the nucleocytoplasmic ratio to cell size regulation.