Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density |
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| Authors: | Feng Pan Peng Xiao Yan Guo Yong-Jun Liu Hong-Yi Deng Robert R Recker " target="_blank">Hong-Wen Deng |
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| Institution: | (1) The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, 710049, People’s Republic of China;(2) Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, NE 68131, USA;(3) Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Room M3-C03, Kansas City, MO 64108-2792, USA;(4) Department of Orthopedic Surgery, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Room M3-C03, Kansas City, MO 64108-2792, USA;(5) Laboratory of Molecular and Statistical Genetics, College of Life Sciences Hunan Normal University, Changsha, Hunan, 410081, People’s Republic of China |
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| Abstract: | Late age at menarche (AAM), an important type of endocrinopathy in females, is associated with lower bone mineral density
(BMD), a major risk factor for osteoporosis. The correlation is mainly mediated through common genetic factors, which are
largely unknown. A bivariate genome-wide linkage scan was conducted on 2,522 females from 414 Caucasian pedigrees to identify
quantitative trait loci influencing both AAM and BMD. The strongest linkage signal was detected on chromosome 22q13. Other
regions such as the 3q13, 3p25, 7p15, and 15q13 were also suggested. The inferred promising candidate genes in the linkage
regions may contribute to our understanding of pathogenesis of endocrinopathy and osteoporosis in females. |
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