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Protective effect of cAMP on tumor promoter-mediated inhibition of cell-cell communication |
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| Authors: | Y Kanno T Enomoto Y Shiba H Yamasaki |
| Institution: | 1. Department of Physiology, Hiroshima University School of Dentistry, Hiroshima 734, Japan;2. Division of Environmental Carcinogenesis, International Agency for Research on Cancer, 69372 Lyon Cedex 08, France |
| Abstract: | The formation and maintenance of electrical cell coupling is inhibited by 100 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA). This inhibition could be prevented by db-cAMP and aminophylline when added together with TPA, though they did not restore the cell coupling once it had already been blocked by TPA. It is suggested that db-cAMP affects the early membrane effects of TPA in FL cells. |
| Keywords: | To whom offprint requests should be sent Adress: Department of Physiology Hiroshima University School of Dentistry 2-3 Kasumi 1 Chome Minami-ku Hiroshima 734 Japan |
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