毛囊干细胞研究进展

毛囊干细胞定位在毛囊隆突部，该部位细胞具有其它成体干细胞的共同特性，即慢周期、未分化、自我更新能力及体外增殖能力强等。CD34，K15，K19和Nestin可能作为毛囊干细胞的表面标记。毛囊干细胞在体外可诱导分化为神经元细胞，神经胶质细胞，角化细胞，平滑肌细胞和黑色素细胞等，而在体内（移植后）可分化为神经元、黑色素细胞等。在毛囊干细胞信号调控中涉及到许多的调控信号，主要包括WNT信号、BMP信号和NFATc1等基因的作用。

The Research Advance of Hair Follicle Stem Cell

Hair follicle stem cells located bulge region of hair follicle, had characteristics of all adult stem cells, including slow-cycling, undifferentiated. They also had the abilities of self-renew and proliferation in vitro. CD34、K15、K19 and Nestin might be the makers of the hair follicle stem cells. They could be induced to differentiate to neurons, glial cells, keratinocytes, smooth muscle cells ,melanocytes In vitro and neurons, melanocytes in vivo. There were many signals in regulating the hair follicle stem cells involved Wnt signal、BMP signal and NFATc1etc.