The effect of post-heparin lipolytic activity on plasma lipoproteins |
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Authors: | Bruno Agostini |
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Affiliation: | (1) Abteilung Physiologie, Max-Planck-Institut für medizinische Forschung, D-6900 Heidelberg, Federal Republic of Germany |
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Abstract: | Summary Electron microscopy of negatively stained plasma shows that intravenous administration of heparin to healthy humans results in a fast degradation of very low density lipoproteins (VLDL), which are very rich in triglycerides (50% w/w). VLDL are also rapidly digested by post-heparin lipolytic activity when serum from non-heparinized subjects is incubated at 27°C in vitro with post-heparin serum of healthy controls.Abbreviations VLDL very low density lipoproteins - LDL low density lipoproteins - HDL high density lipoproteins - LP-X lipoprotein-X, abnormal lipoprotein characterizing obstructive jaundice |
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