Lactobacillus fermentum CRL 722 is able to deliver active alpha-galactosidase activity in the small intestine of rats |
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Authors: | LeBlanc Jean Guy Piard Jean-Christophe Sesma Fernando de Giori Graciela Savoy |
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Affiliation: | Centro de Referencia para Lactobacilos (CERELA-CONICET). Chacabuco 145, San Miguel de Tucumán, Tucumán, Argentina (T4000ILC). leblanc@cerela.org.ar |
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Abstract: | alpha-galactooligosaccharides (alpha-GOS) found in legumes such as soybeans can cause gastrointestinal disorders since mammals lack alpha-galactosidase (alpha-Gal) in the small intestine which is necessary for their hydrolysis. Lactobacillus fermentum CRL 722 is a lactic acid bacterium (LAB) capable of degrading alpha-GOS due to its elevated alpha-Gal activity. When conventional rats were fed live L. fermentum CRL 722 or cell-free extracts of this strain, a short-lived alpha-Gal activity was detected in the upper gastrointestinal tract. The safety of this LAB was also assessed. L. fermentum CRL 722 could thus be used as a vehicle to safely confer alpha-Gal in the small intestine of monogastric animal. |
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Keywords: | α-galactosidase Lactic acid bacteria Soymilk α-GOS Flatulence Gut |
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