CAG polymorphism of the androgen receptor gene in azoospermic and oligozoospermic men from Ukraine |
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| Authors: | O A Fesai S A Kravchenko M Ya Tyrkus G V Makuh V M Zinchenko G V Strelko L A Livshits |
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| Institution: | (1) Division of Endocrinology, Helsinki University Central Hospital, 00290 Helsinki, Finland;(2) Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland;(3) Research Program in Molecular Medicine, University of Helsinki, Helsinki, Finland;(4) Department of Statistics, University of Turku, 20014 Turku, Finland; |
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| Abstract: | An analysis of the number of CAG repeats in exon 1 of the gene was conducted in a group of 228 infertile males with azoospermia
(n = 68) and oligozoospermia (n = 160), and in a control group (124 proven fathers) by means of polymerase chain reaction with subsequent fragment analysis
on an ALF-Express automated fluorescent analyzer. Allele frequency with the number of CAG repeats ≤ 18 was found to be significantly
higher (P < 0.01) in the group of patients with azoospermia (17.7%) as compared to the control group (2.4%), and in the group of patients
with oligozoospermia (12.5%) as compared to the control group (2.4%). Allele frequency with the number of CAG repeats ≥ 28
was shown to be significantly higher (P < 0.01) in patients with oligozoospermia (12.5%) as compared to the control group (2.4%). Our data suggest an association
between the number of CAG repeats and impaired spermatogenesis in azoospermic and oligozoospermic males. |
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