Reverse genetics through random mutagenesis in Histoplasma capsulatum |
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Authors: | Brian H Youseff Julie A Dougherty and Chad A Rappleye |
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Abstract: | Background The dimorphic fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease in humans and other mammals. Progress in understanding the mechanisms underlying
the biology and the pathogenesis of Histoplasma has been hindered by a shortage of methodologies for mutating a gene of interest. |
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