Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection |
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| Authors: | Kalliopi Pitarokoili Bj?rn Ambrosius Daniela Meyer Lisa Schrewe Ralf Gold |
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| Institution: | Department of Neurology, St. Josef Hospital, Ruhr- University of Bochum, Bochum, Germany;LMU Munich, GERMANY |
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| Abstract: | BackgroundDimethyl fumarate is an immunomodulatory and neuroprotective drug, approved recently for the treatment of relapsing-remitting multiple sclerosis. In view of the limited therapeutic options for human acute and chronic polyneuritis, we used the animal model of experimental autoimmune neuritis in the Lewis rat to study the effects of dimethyl fumarate on autoimmune inflammation and neuroprotection in the peripheral nervous system.ConclusionsWe conclude that immunmodulatory and neuroprotective dimethyl fumarate may represent an innovative therapeutic option in human autoimmune neuropathies. |
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