Metabolism of estrone sulfate in the pregnant sheep |
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Authors: | Charles PW Tsang AJ Hackett |
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Institution: | Animal Research Institute Ottawa, Ontario K1A 0C6 Canada |
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Abstract: | The metabolism of 3H-estrone sulfate (3H-E1S) in 4 pregnant sheep, two injected i.v. and two i.m., has been studied. Intravenously injected 3H-E1S had a plasma half-life of approximately 8 min, and metabolic clearance rate of approximately 800 ml/min. Using this clearance rate and the previously published mean plasma concentration of E1S, the estimated production rate of E1S is between 8.8 nmol (3.3 μg) and 78.2 nmol (29.1 μg) per min from 2-day to 0-day before parturition.Intramuscularly injected 3H-E1S disappeared from plasma linearly and was completely cleared well within 3 hours. In all cases, whether i.v. or i.m. injected, the main metabolite isolated was 3H-estradiol-17β-3-sulfate, with only a trace amount as 3H-estradiol-17β-3-sulfate. |
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