Binding and photocleavage of DNA by mixed ligand Co(III) and Ni(II) complexes of thiophene[2, 3-b] quinoline and phenanthrolie/bipyridine |
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| Authors: | Mustur C Prabahkara Halehatty S Bhojya Naik |
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| Institution: | (1) Department of P.G. Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577 451, Shimoga, Karnataka, India |
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| Abstract: | In order to systematically perform an experimental and theoretical study on DNA binding and photocleavage properties of transition
metal complexes of the type M(L)2(L1)](PF6)n · xH2O (where M = Co(III) or Ni(II), L = 1,10-phenanthroline or 2.2′ bipryidine, L1 = Thiophene 2,3-b] quinoline (qt), n = 3 or 2 and x = 5 or 2) have been synthesized and characterized by elemental analysis, IR, 1H NMR, UV and magnetic susceptibility data. The DNA-binding properties of these complexes have been investigated with UV-Vis,
viscosity measurements, thermal denaturation and cyclic voltametric studies. It is experimentally found that all the complexes
are bound to DNA via intercalation in the order Co(bpy)2(qt)](PF6)3 > Co(phen)2(qt)](PF6)3 > Ni(phen)2(qt)](PF6)2 > Ni(bpy)2(qt)](PF6)2. The photocleavage studies with pUC19 DNA shows that all these complexes promoted the conversion of SC form to NC form in
absence of ‘inhibitors’. |
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| Keywords: | Mixed ligand complexes Phenanthroline Bipyridine DNA binding Photocleavage |
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