Precursor-Directed polyketide biosynthesis in Escherichia coli |
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| Authors: | Kinoshita Kenji Pfeifer Blaine A Khosla Chaitan Cane David E |
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| Affiliation: | Department of Chemistry, Box H, Brown University, Providence, RI 02912-9108, USA. |
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| Abstract: | Precursor-directed polyketide biosynthesis was demonstrated in the heterologous host Escherichia coli. Several diketide and triketide substrates were fed to a recombinant E. coli strain containing a variant form of deoxyerythronolide B synthase (DEBS) from which the first elongation module was deleted resulting in successful macrolactone formation from the diketide, but not the triketide, substrates. |
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