Metabolism of prostaglandins in the rat liver during ethanol withdrawal

The 9-month intake of a 5% ethanol solution as a source of fluid resulted in the essential fatty acid deficiency, a decrease in the prostaglandins E and F2 alpha level and in the activities of the corresponding prostaglandin synthetases and linoleyl-CoA desaturases in the rat liver. Eight days after ethanol withdrawal the indices of prostaglandin metabolism become normal, whereas the arachidonic acid concentration and the linoleyl-CoA desaturase activity increase.