Automatically extracting functionally equivalent proteins from SwissProt |
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Authors: | Lisa EM McMillan Andrew CR Martin |
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Institution: | (1) Research Department of Structural & Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK |
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Abstract: | Background There is a frequent need to obtain sets of functionally equivalent homologous proteins (FEPs) from different species. While
it is usually the case that orthology implies functional equivalence, this is not always true; therefore datasets of orthologous
proteins are not appropriate. The information relevant to extracting FEPs is contained in databanks such as UniProtKB/Swiss-Prot
and a manual analysis of these data allow FEPs to be extracted on a one-off basis. However there has been no resource allowing
the easy, automatic extraction of groups of FEPs – for example, all instances of protein C. |
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Keywords: | |
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