The GraRS regulatory system controls <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> susceptibility to antimicrobial host defenses期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The GraRS regulatory system controls <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> susceptibility to antimicrobial host defenses

Authors:	Dirk Kraus Silvia Herbert Sascha A Kristian Arya Khosravi Victor Nizet Friedrich Götz Andreas Peschel

Institution:	1.Cellular and Molecular Microbiology Division,Institute for Medical Microbiology and Hygiene, University of Tübingen,Tübingen,Germany;2.Microbial Genetics,University of Tübingen,Tübingen,Germany;3.Departments of Pediatrics,University of California,La Jolla,USA;4.Veterans Affairs San Diego Healthcare System,La Jolla,USA

Abstract:	Background Modification of teichoic acids with D-alanine by the products of the dlt operon protects Gram-positive bacteria against major antimicrobial host defense molecules such as defensins, cathelicidins, myeloperoxidase or phospholipase. The graRS regulatory genes have recently been implicated in the control of D-alanylation in Staphylococcus aureus.

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