Self-association of an activating natural killer cell receptor, KIR2DS1 |
| |
Authors: | Hayley Michael Bourbigot Sarah Booth Valerie |
| |
Affiliation: | Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada. |
| |
Abstract: | As a major component of the innate immune system, natural killer cells are responsible for activating the cytolytic killing of certain pathogen-infected or tumor cells. The self-recognition of natural killer cells is achieved in part by the killer cell immunoglobulin-like receptors (KIRs) protein family. In the current study, using a suite of biophysical methods, we investigate the self-association of an activating KIR, KIR2DS1. This KIR is of particular interest because when in the presence of the HLA-Cw6 protein, KIR2DS1 becomes a major risk factor for psoriasis, an autoimmune chronic skin disease. Using circular dichroism spectroscopy, dynamic light scattering, and atomic force microscopy, we reveal that KIR2DS1 self-associates in a well-defined fashion. Our novel results on an activating KIR allow us to suggest a working model for the KIR2DS1- HLA class I molecular mechanism. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|