Type IX collagen is a potent inducer of PGE2 and interleukin 1 production by human monocyte macrophages |
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| Authors: | J M Dayer S Ricard-Blum M T Kaufmann D Herbage |
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| Institution: | 1. Division of Immunology and Allergy (Hans Wilsdorf Laboratory), Department of Medicine, University Hospital Cantonal, 1211 Geneva 4, Switzerland;2. UA CNRS 244, Université Claude Bernard Lyon I, Lyon, France |
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| Abstract: | Type IX collagen and its collagenous fragments are potent stimulatory agents on human blood mononuclear cells for the production of prostaglandin E2 and interleukin 1/mononuclear cell factor. Type IX collagen is 2-4-fold more potent that type I and II and 1 alpha-, 2 alpha- and 3 alpha-collagens. This property may be important in the destructive process of cartilage in inflammatory diseases. |
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