Inhibition of the prostaglandin-liberating activity of bradykinin in the rat]

In the rat, hydrocortisone, dexamethasone and chloroquine do not inhibit the hypotensive activity of arachidonic acid, which is due to endogenous prostaglandin synthesis. They reduce or suppress the secondary hypotensive phase induced by bradykinin. These substances inhibit the prostaglandin releasing activity of bradykinin but do not interfere with prostaglandin synthesis.