Regulation of resistance to leprosy by chromosome 1 locus in the mouse |
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| Authors: | Emil Skamene Philippe Gros Adrien Forget Parsottam J Patel Muriel N Nesbitt |
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| Institution: | (1) Montreal General Hospital Research Institute, H3G IA4 Montreal, Quebec, Canada;(2) Department of Microbiology and Immunology, University of Montreal, H3C 3J7 Montreal, Quebec, Canada;(3) Department of Microbiology, Mehary Medical College, 37208 Nashville, Tennessee;(4) Department of Biology, University of California, 92093 La Jolla, California;(5) Montreal General Hospital, 1650 Cedar Avenue, H3G IA4 Montreal, Quebec, Canada |
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| Abstract: | Mice of different inbred strains vary in their resistance to intravenous infection with Mycobacterium lepraemurium (MLM). The mean survival time of MLM-infected A/J and DBA/2 mice is significantly longer than that of similarly infected C57BL/6 and BALB/c mice. The typing of AXB/BXA recombinant inbred strains (A = A/J, B = C57BL/6) for the trait of relative resistance/susceptibility to MLM revealed a perfect match with the strain distribution pattern of resistance/susceptibility to Mycobacterium bovis (BCG), the trait which is controlled by the Bcg (Ity, Lsh) locus on chromosome 1. The control, by this gene, of response to MLM was further confirmed by the demonstration that BALB/c-Bcg
r
congenic mice,which carry the DBA/2-derived Bcg
r
(resistant) allele on chromosome 1, are significantly more resistant to MLM infection than their BALB/c (Bcg
s
, susceptible) counterparts. |
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