Rate sensitivity of blood pressure to hypoxia |
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Authors: | V Licko H Raff |
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Affiliation: | Cardiovascular Research Institute, Liver Center and Department of Physiology, University of California, San Francisco CA 94143, U.S.A. |
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Abstract: | A biochemical kinetic model is used to describe changes in mean arterial blood pressure in dogs to three different rates of fall of arterial partial pressure of oxygen. The model is a linear loop with one variable rate coefficient (parametric control) which has been previously shown to characterize the rate sensitivity to presented stimuli. A three component model was identified under a least squares criterion and it showed that a unique (stimulation independent) representation can be obtained which can serve as a conceptual framework for the study of this phenomenon. |
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Keywords: | To whom correspondence should be addressed. |
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