The depletion attraction: an underappreciated force driving cellular organization |
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| Authors: | Marenduzzo Davide Finan Kieran Cook Peter R |
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| Affiliation: | School of Physics, University of Edinburgh, Edinburgh, EH9 3JZ, Scotland, UK. |
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| Abstract: | Cellular structures are shaped by hydrogen and ionic bonds, plus van der Waals and hydrophobic forces. In cells crowded with macromolecules, a little-known and distinct force-the "depletion attraction"-also acts. We review evidence that this force assists in the assembly of a wide range of cellular structures, ranging from the cytoskeleton to chromatin loops and whole chromosomes. |
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