| 抑制素基因的研究进展 |
| |
| 引用本文： | 薛昱,储明星,周忠孝. 抑制素基因的研究进展[J]. 遗传, 2004, 26(5): 749-755 |
| |
| 作者姓名： | 薛昱 储明星 周忠孝 |
| |
| 作者单位： | 1.山西农业大学动物科技学院，山西 太谷 030801； 2. 中国农业科学院畜牧研究所，北京 1000941.College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030801, China;2. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China |
| |
| 基金项目： | 北京市自然科学基金，国家高技术研究发展计划(863计划) |
| |
| 摘 要： | 抑制素是性腺分泌的一种糖蛋白激素，它具有抑制垂体促卵泡素合成和分泌的作用。本文介绍了抑制素α亚基基因（INHA）、抑制素βA亚基基因（INHBA）、抑制素βB亚基基因（INHBB）的克隆、结构、定位、多态性、表达、分子调节及其与繁殖性能和癌症的关系。绵羊INHA、INHBA和INHBB基因分别被定位到2q41→q43、4q26和2q31→q33。INHA、INHBA和INHBB基因对绵羊产羔数都有显著的影响。抑制素βB亚基基因突变的雌性小鼠有明显的发育和繁殖缺陷。INHA 基因与妇女卵巢早衰显著相关。Abstract：Inhibins are gonadal glycoprotein hormones belonging to the transforming growth factor-βsuperfamily that act to suppress pituitary follicle-stimulating hormone synthesis and secretion. In this paper, we briefly introduced the cloning, structure, localization, polymorphism, expression, molecular regulation of inhibin-α(INHA), -βA (INHBA) and -βB (INHBB) subunit genes and their relationships with reproductive performance and cancer.The inhibin genes (INHA, INHBA and INHBB) had significant effect on litter size in sheep. The ovine INHA, INHBA and INHBB genes had been mapped to chromosomes 2q41→q43, 4q26 and 2q31→q33, respectively. The female mice carrying INHBB mutations suffered from distinct developmental and reproductive defects. The INHA gene was significantly associated with premature ovarian failure in women.
|
| 关 键 词： | 抑制素 抑制素基因 繁殖性能 inhibin 癌症Key words |
| 文章编号： | 0253-9772(2004)05-0749-07 |
| 修稿时间： | 2003-07-07 |
Advances on Inhibin Genes |
| |
| XUE Yu,CHU Ming-Xing,ZHOU Zhong-Xiao. Advances on Inhibin Genes[J]. Hereditas, 2004, 26(5): 749-755 |
| |
| Authors: | XUE Yu CHU Ming-Xing ZHOU Zhong-Xiao |
| |
| Affiliation: | College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030 801, China. xueyu7908@yahoo.com.cn |
| |
| Abstract: | Inhibins are gonadal glycoprotein hormones belonging to the transforming growth factor-beta superfamily that act to suppress pituitary follicle-stimulating hormone synthesis and secretion. In this paper, we briefly introduced the cloning, structure, localization, polymorphism, expression, molecular regulation of inhibin-alpha(INHA), -betaA (INHBA) and -beta B (INHBB) subunit genes and their relationships with reproductive performance and cancer. The inhibin genes (INHA, INHBA and INHBB) had significant effect on litter size in sheep. The ovine INHA, INHBA and INHBB genes had been mapped to chromosomes 2q41-->q43, 4q26 and 2q31-->q33, respectively. The female mice carrying INHBB mutations suffered from distinct developmental and reproductive defects. The INHA gene was significantly associated with premature ovarian failure in women. |
| |
| Keywords: | inhibin inhibin gene reproductive performance cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
|
点击此处可从《遗传》下载全文 |
|
