Increased digitalis-like activity in human cerebrospinal fluid after expansion of the extracellular fluid volume |
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Authors: | J A Halperin A M Martin S Malave |
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Institution: | Unidad de Investigaciones and Unidad de Radiodiagnostico, Centro Medico Docente La Trinidad, A.P. 80474, Caracas 1080 A, Venezuela |
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Abstract: | The present study was designed to determine whether acute expansion of the extracellular fluid volume influenced the digitalis-like activity of human cerebrospinal fluid (CSF), previously described by our laboratory. Human CSF samples, drawn before and 30 minutes after the intravenous infusion of 1 liter of either saline or glucose solutions, were assayed for digitalis-like activity by inhibition of either the 86Rb+ uptake into human erythrocytes or by the activity of a purified Na+ - K+ ATPase. The CSF inhibitory activity on both systems significantly increased after the infusion of sodium solutions but did not change after the infusion of glucose. These results indicate that the digitalis-like factor of human CSF might be involved in the regulation of the extracellular fluid volume and electrolyte content and thereby in some of the physiological responses to sodium loading. |
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