Iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase |
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| Authors: | R P Magnusson A Taurog |
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| Affiliation: | Department of Pharmacology, University of Texas Health Science Center, Dallas, Texas 75235 USA |
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| Abstract: | Thyroid peroxidase (TPO) and lactoperoxidase (LPO) display significant catalatic activity at pH 7.0 in the presence of low concentrations of iodide, based both on measurements of H2O2 disappearance and O2 evolution. In the absence of iodide only minor catalatic activity was detected. The stimulatory effect of iodide could not be explained by protection of the enzymes against inactivation by H2O2. A mechanism is suggested involving an enzyme-hypoiodite complex as an intermediate. |
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| Keywords: | TPO thyroid peroxidase LPO lactoperoxidase CPO chloroperoxidase |
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