A tandemly repetitive DNA sequence is present at diverse locations in the genome of Ostertagia circumcincta |
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| Institution: | 1. State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi''an 710061, China;2. Shaanxi Key Laboratory of Accelerator Mass Spectrometry and Application, Xi''an AMS Center, Xi''an 710061, China;3. CAS Center for Excellence in Quaternary Science and Global Change,Xi''an, 710061, China;4. Department of Geography, School of Global Studies, University of Sussex, Falmer, Brighton BN1 9QJ, UK;5. Department of Earth System Science, Institute for Global Change Studies, Tsinghua University, Beijing 100084, China;6. School of Geography, Geomatics, and Planning, Jiangsu Normal University, Xuzhou 221116, China |
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| Abstract: | A novel repetitive DNA sequence in the sheep parasitic nematode Ostertagia circumcincta was cloned and sequenced. This 1.2-kb sequence (Oc1B) was not found in the closely related cattle parasite Ostertagia ostertagi, nor in the more distantly related sheep parasites Haemonchus contortus or Trichostrongylus colubriformis. Sequences similar to Oc1B were found at various genomic locations and contained a pair of 33-bp direct repeats. Oc1B also contained a single copy of a 218-bp sequence (designated OcREP) which was present in 100 to 200 copies in the O. circumcincta genome and mostly organized in distinctive tandem arrays. The dual organizational pattern of OcREP as both a satellite-like sequence as well as interspersed as single copies amongst dissimilar sequences adds to the growing evidence for the fluidity of the parasitic nematode genome, and of eukaryotic genomes in general. |
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