Distribution and variability of trinucleotide repeats in the genome of the yeast Saccharomyces cerevisiae |
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| Affiliation: | 1. Brain Korea 21 Center for Bio-resource Development, Division of Animal, Horticultural, and Food Sciences, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea;2. Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon, 14662, Republic of Korea;1. Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, India;2. Department of Botany, University of Lucknow, India;3. Plant Ecology and Environmental Technology Division, CSIR-National Botanical Research Institute, India;1. CCMAR – Centre of Marine Sciences, University of Algarve, Gambelas, 8005-139 Faro, Portugal;2. Necton S.A., Belamandil, 8700-152 Olhão, Algarve, Portugal;3. LEPABE – Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering of the University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal;4. USC – Instituto de Acuicultura y Departamento de Microbiología y Parasitología, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain;5. GreenCoLab - Associação Oceano Verde, University of Algarve, Campus de Gambelas, Faro, Portugal;1. Laboratory of Microbiology and Food Biocatalysis, Institute of Food Science Research (CIAL, CSIC-UAM), Nicolás Cabrera, 9. UAM Campus, Cantoblanco, 28049, Madrid, Spain;2. Department of Biocatalysis, Institute of Catalysis and Petrochemistry (ICP, CSIC), Marie Curie, 2. UAM Campus, Cantoblanco, 28049, Madrid, Spain;1. Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, 400084, India;2. Department of Biological Sciences, Birla Institute of Technology & Science Pilani, K. K. Birla Goa Campus, Goa, 403726, India;3. Department of Biological Sciences and Biotechnology, Institute of Advanced Research (IAR), Gandhinagar, Gujarat, 382426, India;4. Institute of Experimental Botany of the Czech Academy of Sciences, 16502 Prague 6, Czech Republic |
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| Abstract: | We have examined the distribution of trinucleotide repeats in the yeast genome. Perfect and imperfect repeats, ranging from four to 130 triplets were recognized and the repartition of different triplet combinations was found to differ between Open Reading Frames and Intergenic Regions. Examination of different laboratory strains, revealed polymorphic size variations for all perfect repeats studied, compared to an absence of variation for the imperfect ones. Size variations were found discrete in the range of 6–18 triplets, each strain showing one allelic form for a given repeat array. The distribution and stability of trinucleotide repeats in the yeast genome resembles that of humans and may provide an experimental approach to study the mechanisms of their expansion. |
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