A modular positive feedback-based gene amplifier |
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| Authors: | Goutam J Nistala Kang Wu Christopher V Rao Kaustubh D Bhalerao |
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| Institution: | (1) Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 W Pennsylvania Ave, Urbana, IL 61801, USA;(2) Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 1304 W Pennsylvania Ave, Urbana, IL 61801, USA |
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| Abstract: | Background Positive feedback is a common mechanism used in the regulation of many gene circuits as it can amplify the response to inducers
and also generate binary outputs and hysteresis. In the context of electrical circuit design, positive feedback is often considered
in the design of amplifiers. Similar approaches, therefore, may be used for the design of amplifiers in synthetic gene circuits
with applications, for example, in cell-based sensors. |
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