Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration |
| |
| Authors: | Xiaoxia Li Wei Wang Guoqiang Wei Guanxiong Wang Weiguo Zhang and Xiaojun Ma |
| |
| Institution: | (1) Lab of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China;(2) Graduate School of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China;(3) Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China;(4) School of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China; |
| |
| Abstract: | Immunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective
actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative response
than the guide with no FK506. The drug was entrapped in the semi-permeable wall of chitosan guide with the drug-loading of
647 μg/g. Rat sciatic nerve defect model treated with FK506-releasing chitosan guide showed more mature appearance of myelinated
fibers 8 weeks after surgery; furthermore, the motor functional reinnervation occurred, the amplitude and velocity of compound
muscle action potentials reached 60% and 73% with respect to the normal. Thus, FK506-releasing chitosan guide should be acted
as a long-lasting delivery device of immunosuppressive and neuroregenerative agent for peripheral nerve repair. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
