| 成纤维细胞生长因子与其受体相互作用及其抑制剂的研究进展 |
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| 引用本文： | 范洪宽,周慧,李惟.成纤维细胞生长因子与其受体相互作用及其抑制剂的研究进展[J].生物化学与生物物理进展,2001,28(3):338-341. |
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| 作者姓名： | 范洪宽 周慧 李惟 |
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| 作者单位： | 吉林大学生命科学学院，长春 130023;吉林大学生命科学学院，长春 130023;吉林大学生命科学学院，长春 130023 |
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| 基金项目： | 国家自然科学基金资助项目(39670853). |
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| 摘 要： | 成纤维细胞生长因子（FGF）有许多重要的生理功能，并与肿瘤的形成有关.为了弄清FGF与成纤维细胞生长因子受体(FGFR)相互作用的机制，人们对FGF和FGFR的各个结合结构域进行了深入、细致的研究，定位了aFGF、bFGF的肝素结合区、bFGF的受体结合区、FGF受体的肝素结合区、配体结合区和FGF受体相互结合区，提出了两个FGF与FGFR相互作用的模型，在此基础上设计了FGF的核酸类、糖类和多肽类抑制剂，为寻找新一代抗癌药物打下了理论基础.
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| 关 键 词： | 成纤维细胞生长因子，受体，肝素，抑制剂 |
| 收稿时间： | 2000/6/26 0:00:00 |
| 修稿时间： | 2000/8/23 0:00:00 |
The Interaction of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor and FGF Inhibitors |
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| FAN Hong-Kuan,ZHOU Hui and LI Wei.The Interaction of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor and FGF Inhibitors[J].Progress In Biochemistry and Biophysics,2001,28(3):338-341. |
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| Authors: | FAN Hong-Kuan ZHOU Hui and LI Wei |
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| Institution: | College of Life Science, JiLin University, Changchun 130023, China;College of Life Science, JiLin University, Changchun 130023, China;College of Life Science, JiLin University, Changchun 130023, China |
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| Abstract: | The fibroblast growth factor (FGF) family contains at least nineteen members that play important roles in embryogenesis, vascularization, neuron system growth and in development and pathological states. In order to study the mechanism of interaction of FGF/FGFR, plenty of research work was focused on the study of structure and function of FGF and FGFR. Heparin binding domain of aFGF and bFGF, and receptor binding domain of bFGF have been identified. Heparin binding domain and ligands binding domain of FGFR also were localized. Based on the research, two models of interaction of FGF/FGFR were presented and many nucleotide, saccharides and peptide inhibitors were developed. The inhibitors may play an important role in the designing of anti-cancer drug. |
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| Keywords: | fibroblast growth factor receptor heparin inhibitor |
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