1. Tata Memorial Center, Radiation Oncology, ACTREC, Navi Mumbai, India;2. Tata Memorial Hospital, Gynecology Oncology, Mumbai, India;3. Tata Memorial Hospital, Surgical Pathology, Cytopathology, Mumbai, India;4. Biophotonics Laboratory, National Centre for Earth Science Studies, Thiruvananthapuram, Kerala, India;5. Chilakapati Laboratory, ACTREC, Navi Mumbai, India;6. Sascan Meditech Pvt Ltd, Centre for Innovation in Medical Electronics, BMS College of Engineering, Bangalore, India
Abstract:
Optical spectroscopic techniques show improved diagnostic accuracy for non‐invasive detection of cervical cancers. In this study, sensitivity and specificity of two in vivo modalities, i.e diffuse reflectance spectroscopy (DRS) and Raman spectroscopy (RS), were compared by utilizing spectra recorded from the same sites (67 tumor (T), 22 normal cervix (C), and 57 normal vagina (V)). Data was analysed using principal component – linear discriminant analysis (PC‐LDA), and validated using leave‐one‐out‐cross‐validation (LOOCV). Sensitivity, specificity, positive predictive value and negative predictive value for classification between normal (N) and tumor (T) sites were 91%, 96%, 95% and 93%, respectively for RS and 85%, 95%, 93% and 88%, respectively for DRS. Even though DRS revealed slightly lower diagnostic accuracies, owing to its lower cost and portability, it was found to be more suited for cervical cancer screening in low resource settings. On the other hand, RS based devices could be ideal for screening patients with centralised facilities in developing countries.
