Fluoride or/and aluminum induced toxicity in guinea pig teeth with the low expression of dentine phosphoprotein |
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| Authors: | Tianlong Han Min Wang Chunfang Cao Huacheng Chen Guanghe Zhang Liping Wang Jundong Wang |
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| Affiliation: | 1. Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, People's Republic of China;2. Chifeng Academy of Agriculture and Animal Husbandry Sciences, Chifeng, Inner Mongolia, People's Republic of China;3. Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, People's Republic of China |
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| Abstract: | This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or/and aluminum (Al). Fifty‐two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150 mg NaF/L) or/and Al (300 mg AlCl3/L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly. F induced the mottled enamel and irregular abrasion of teeth, which might occur as a consequence of depressed DSPP mRNA and DPP protein expression. Both the gene and protein expressions showed obvious decrease induced by Al, especially by F. There were no synergistic effects between F and Al, instead, Al inhibited the toxicity of F. |
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| Keywords: | aluminum dentine phosphoprotein fluoride guinea pig teeth |
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