Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats |
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| Authors: | Umit M. Kocyigit Ahmet Şevki Taşkıran Parham Taslimi Ahmet Yokuş Yusuf Temel İlhami Gulçin |
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| Affiliation: | 1. Vocational School of Health Services, Cumhuriyet University, Sivas, Turkey;2. Department of Physiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey;3. Department of Chemistry, Faculty of Sciences, Ataturk University, 25240‐Erzurum, Turkey;4. Vocational School of Y?ld?zeli, Cumhuriyet University, Sivas, Turkey;5. Vocational School of Solhan, Bingol University, Bingol, Turkey |
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| Abstract: | The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT‐atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in liver and kidney tissues of rats. For this purpose, four different groups, each consisting of six rats (n = 6), were formed (control group, OT administered group, atosiban administered group, and both OT and atosiban administered group). The rats were necropsied 60 min after intraperitoneal injection of chemicals into the rats. Liver tissues of rats were extracted. CA and AChE enzyme activities were measured for each tissue by using hydratase, esterase, and acetylcholiniodide methods. Activity values for each enzyme obtained were statistically calculated. |
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| Keywords: | Enzyme activity carbonic anhydrase oxytocin rat |
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