Platycodin D,a triterpenoid saponin from Platycodon grandiflorum,suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF‐κB pathway |
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Authors: | Zhiyong Zhang Minchao Zhao Wenxuan Zheng Yonghong Liu |
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Affiliation: | 1. Department of Oral Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China;2. Department of Stomatology, The Third Affiliated Hospital to Hebei Medical University, Shijiazhuang, People's Republic of China;3. Department of Oral Medicine, Hengshui Harrison International Peace Hospital, Hengshui, People's Republic of China |
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Abstract: | This work was undertaken to explore the effects of platycodin D, a triterpenoid saponin from Platycodon grandiflorum, on the growth and invasiveness of human oral squamous cell carcinoma (OSCC). Platycodin D caused a significant, concentration‐dependent inhibition of cell viability and induced significant apoptosis in OSCC cells. Moreover, platycodin D significantly inhibited OSCC cell invasion. At the molecular level, platycodin D increased the amounts of IκBα protein and reduced the expression of phosphorylated NF‐κB p65, MMP‐2, and MMP‐9. Ectopic expression of constitutively active NF‐κB p65 prevented platycodin D‐mediated induction of apoptosis and suppression of invasion in OSCC cells. In vivo studies confirmed that platycodin D retarded the growth of subcutaneous SCC‐4 xenograft tumors and reduced phosphorylation of NF‐κB p65. Altogether, platycodin D shows inhibitory activity on OSCC growth and invasion through inactivation of the NF‐κB pathway and might provide therapeutic benefits in the treatment of OSCC. |
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Keywords: | Growth invasiveness NF‐κ B signaling oral cancer platycodin D |
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