Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue |
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| Authors: | Guanping Feng Marien Ochoa Jason R. Maher Hani A. Awad Andrew J. Berger |
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| Affiliation: | 1. The Institute of Optics, University of Rochester, New York;2. Department of Biomedical Engineering, University of Rochester, New York;3. The Center for Musculoskeletal Research, University of Rochester Medical Center, New York |
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| Abstract: | The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non‐invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth‐resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease‐related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements. |
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| Keywords: | spatially offset Raman spectroscopy bone osteogenesis imperfecta |
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