Endocrine regulation of trace element homeostasis in the rat

Conclusion The mechanisms responsible for the modifications of the concentrations of elements in tissues induced by hormonal influences are complex, because each hormone has pleiotropic actions that are sometimes opposite. Among these modifications, it is often difficult to distinguish between the adaptive defensive changes and the changes responsible for disorders or for exacerbating them, for example, Fe accumulation in tissues after HPX, TPTX, and castration. Moreover, in clinical conditions, hormonal disturbances are often enhanced by other defects, such as an excessive or a deficient intake of elements.