Increased frequency of X-bearing sperm in males from an infertility clinic: analysis by two-color fluorescence in situ hybridization |
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Authors: | Johannisson R Leuschner E Hüppe M Hinrichs F Al-Hasani S Diedrich K Schwinger E Mennicke K |
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Affiliation: | Institute of Pathology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. johannisson@patho.mu-luebeck.de |
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Abstract: | Semen samples from 34 men visiting the Lübeck infertility clinic were investigated using a two-color FISH method to determine the ratio of X- and Y-bearing sperm. The overall ratio was significantly shifted to a preponderance of X-containing sperm. A statistical comparison with seven reports from the literature which included 53 normal probands demonstrated in our patients a significant tendency of a preponderance of X-bearing sperm and significantly less Y-bearing sperm. Furthermore, the Lübeck sperm samples are remarkably more heterogeneous in respect to their variability of X- and Y-bearing spermatozoa than in the other mentioned studies with normal probands. These phenomena have to be evaluated in further studies on groups of infertile males showing similar infertility histories. |
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