FAK/mTOR信号通在肿瘤细胞中的调控作用

粘附斑激酶（focal adhesion kinase，FAK）是一种胞质非受体酪氨酸激酶，是整合素信号通路里一个重要的调节因子，在肿瘤细胞中高表达，与细胞迁移、粘附和侵袭有关。mTOR (mammalian target of rapamycin)是非典型性的Ser/Thr激酶，属于PIKK（phosphatidylinositol kinase related kinase）超家族，介导营养信号调控细胞生长、分化及代谢等生理过程。近年的研究发现FAK通过三条途径与mTOR相关联，组成FAK/mTOR信号通路，在肿瘤细胞的增殖、迁移及肿瘤微环境中发挥着重要的调控作用。本文综述了FAK、mTOR和FAK/mTOR信号通路的特点及对肿瘤细胞调控作用的研究概况，为肿瘤治疗提供参考。

FAK/mTOR Signaling and Its Role in Regulation of Tumor Cells

Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor protein tyrosine kinase, which is identified as a key mediator of integrin signaling pathways. FAK is overexpressed in cancer cells and related migration, adhesion and invasion of tumor cells. The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr kinase, and belongs to the phosphatidylinositol kinase related kinase (PIKK) superfamily. mTOR integrate signals from growth factors, nutrition and energy to regulate cell growth, differentiation and metabolism. FAK was found to be associated with mTOR to form FAK/mTOR signaling mediated by three pathways, which plays an important role in regulation of tumor cell proliferation, migration and microenviroment. This paper reviewed the characteristics FAK, mTOR and FAK/mTOR signaling pathway and the role of FAK/mTOR signaling on regulation of tumor cells, providing a reference for cancer therapy.