蛋白激酶C-δ在细胞凋亡中的作用及其分子机制

蛋白激酶C-δ（protein kinase C-δ, PKC-δ）是细胞内重要的信号转导分子，在动物体内广泛表达，具有多种重要的细胞功能，如细胞增殖、死亡和免疫等，尤其在细胞凋亡中扮演重要的角色。在细胞凋亡过程中，PKC-δ可通过构象变化或天冬氨酸特异性半胱氨酸蛋白酶-3（caspase-3）剪切等过程被激活。激活的PKC-δ由细胞质向线粒体或细胞核进行转位。被caspase-3切割的PKC-δ，产生具有激酶活性的催化片段（PKC-δ-catalytic fragment, PKC-δ-CF），作用于下游底物蛋白质，活化促凋亡相关的调控因子，促进细胞凋亡；同时PKC-δ还具有抗凋亡的调控功能。本文对PKC-δ在细胞凋亡中的作用与分子机制及在肿瘤发生与治疗中的作用进行综述，以期为进一步明确PKC-δ在细胞凋亡中的作用机制提供资料。

The Function and Mechanism of Protein Kinase C-δ in Apoptosis

Protein kinase C-δ(PKC-δ) is an important signal transduction molecule in cells that is widely expressed in animals. It performs a variety of significant cellular functions, including cell proliferation, cell death, and immunity；it plays an especially important role in apoptosis. In the process of cell apoptosis, PKC-δ can be activated via a conformational change or by proteolytic cleavage by caspase-3. The activated PKC-δ can translocate from the cytoplasm to either a mitochondrion or the nucleus. The PKC-δ-catalytic fragment(PKC-δ-CF), which is cleaved by caspase-3 from PKC-δ, has kinase activity and acts on downstream substrate proteins, activating pro-apoptotic regulatory factors to promote apoptosis. Meanwhile, PKC-δ itself regulates anti-apoptosis processes. This review will focus on the function and molecular mechanisms of PKC-δ in apoptosis and its role in tumor occurrence and treatment. which will provide basic data for further clarifying the mechanism of PKC-δ in apoptosis.