Inhibition of yeast-mycelium transformation by 2-alkylthio-6-amino-and 2-alkylthio-6-formamidobenzothiazoles and theirin vitro antifungal activity |
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| Authors: | T Kuchta H Bujdáková E Sidóová |
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| Institution: | (1) Department of Microbiology, Virology and Immunology, Faculty of Science, Comenius University, 842 15 Bratislava, Czechoslovakia;(2) Institute of Chemistry, Comenius University, 842 15 Bratislava, Czechoslovakia |
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| Abstract: | The antifungal effect of 2-alkylthio-6-amino-and 2-alkylthio-6-formamidobenzothiazoles (22 derivatives in all) onAspergillus niger and variousCandida yeasts was tested. No significant effect was observed withA. niger. With the pathogenic yeast speciesC. albicans andC. guilliermondii, the most efficient derivatives (6-formamido-2-propylthio-, 6-formamido-2-butylthio-, 6-formamido-2-pentylthio-and 6-formamido-2-isopentylthiobenzothiazole)
exhibited ED50 values in the range from 2.2 to 21 mg/L and were thus 3–35 times more efficient than 2-mercaptobenzothiazole (Dermacid) that
is normally used. 6-Amino-2-pentylthiobenzothiazole was found to be an efficient specific inhibitor of the transformation
of the yeast form ofC. albicans to its mycelial one, IC95(M) being 10 mg/L, which was a concentration 25 times lower than MICY+M. |
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