| 中国西伯利亚幼獭肝内接种美国土拨鼠肝炎病毒的实验研究 |
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| 引用本文： | 金志宏,赵国龙,熊诗松,寇平原,马丽丽,陈洪涛,齐建英,巴秋菊,买凯.中国西伯利亚幼獭肝内接种美国土拨鼠肝炎病毒的实验研究[J].病毒学报,1987(4). |
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| 作者姓名： | 金志宏 赵国龙 熊诗松 寇平原 马丽丽 陈洪涛 齐建英 巴秋菊 买凯 |
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| 作者单位： | 河南医科大学河南省医学科学研究所
(金志宏，赵国龙，熊诗松，寇平原，马丽丽，陈洪涛，齐建英，巴秋菊)，河南医科大学河南省医学科学研究所(买凯) |
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| 摘 要： | 研究肝炎和肝癌关系的实验动物中,唯有土拨鼠感染土拨鼠肝类病毒(WoodchuckHepatitis Virus,WHv)后,其病程、结局与人类感染乙型肝炎病毒(HBV)相似,WHV DNA可与宿主肝细胞DNA整合并产生肝癌。中国旱獭(Marmota marmota)在
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| 关 键 词： | 西伯利亚旱獭 土拨鼠肝炎病毒 |
EXPERIMENTAL TRANSMISSION OF WOODCHUCK HEPATITIS VIRUS TO YOUNG CHINESE MARMOTS ( MARMOT A BOBAK SIBIRICA RADDE ) BY INTRAHEPATIC INOCULATION |
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| Jin Zhihong Zhao Guolong Xiong Shisong Kou Pingyuan Ma Lili Chen Hongtao Qi Jianying Ba Qiuju Mai Kai.EXPERIMENTAL TRANSMISSION OF WOODCHUCK HEPATITIS VIRUS TO YOUNG CHINESE MARMOTS ( MARMOT A BOBAK SIBIRICA RADDE ) BY INTRAHEPATIC INOCULATION[J].Chinese Journal of Virology,1987(4). |
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| Authors: | Jin Zhihong Zhao Guolong Xiong Shisong Kou Pingyuan Ma Lili Chen Hongtao Qi Jianying Ba Qiuju Mai Kai |
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| Abstract: | Fourteen young Chinese marmots ( Marmota bobak sibirica Radde ) were randomly allocated into two groups of 7 each. Standard challenge pool prepared from sera of woodchucks infected with woodchuck hepatitis virus (WHV) and negative control pool were inoculated into the two groups respectively. WHsAg, anti-WHs were detected by RIA in the serum of one of the animals challenged with the standard pool. WHsAg particles of both spherical and filamentous forms and WHV virions were found in its serum under electromicroscope. These results suggest that young Chinese marmots may be sensitive to WHV. |
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| Keywords: | Siberian marmot Woodchuck hepatitis virus |
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