A chlorinated phenylpyrrole antibiotic fromActinoplanes |
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Authors: | Bruno Cavalleri Giancarlo Volpe Giogio Tuan Marisa Berti Francesco Parenti |
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Affiliation: | (1) Research Laboratories, Gruppo Lepetit SpA, Via Durando, 38, 20158 Milano, Italy |
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Abstract: | Two chlorophenyl-containing antibiotics have been isolated from a strain ofActinoplanes (ATCC 33002). Antibiotic A 15104 Y is a chlorinated phenylpyrrole compound whose structure has been confirmed by chemical synthesis. Antibiotic A 15104 Z is a chlorophenol derivative for which a structural formula is proposed on the basis of its physicochemical properties. A 15104 Y shows antimicrobial activity against Gram-positive, Gram-negative, and acid-fast bacteria, yeasts, fungi, and protozoa, while A 15104 Z possesses a low activity against Gram-positive bacteria andTrichophyton. A 15104 Y has a weak activity in curing experimentally infected mice, at a dose that is one-fifth the LD50 for the same species. This is the first example of a chloropyrrole derivative isolated from an actinomycete. |
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