High-performance liquid chromatographic determination of penicillamine in whole blood, plasma, and urine |
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| Authors: | Richard F Bergstrom Donald R Kay John G Wagner |
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| Institution: | Upjohn Center For Clinical Pharmacology and College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109 U.S.A. |
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| Abstract: | A high-performance liquid chromatographic method for the determination of penicillamine in plasma, whole blood, and urine samples is described. The method uses a commercially available electrochemical detector at a potential of +0.1 V versus the Ag/AgCl reference electrode. This method is selective and sensitive for sulfhydryl compounds. The chromatography separates penicillamine from other endogenous sulfhydryl compounds with a limit of detection for penicillamine in biological samples of ca. 10−7M. |
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| Keywords: | Author for correspondence at the Upjohn Center |
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