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Specificity of xenoreactive anti-Gal{alpha}1-3Gal IgM for {alpha}-galactosyl ligands |
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| Authors: | Parker, William Lateef, Jarama Everett, Mary Lou Platt, Jeffrey L. |
| Affiliation: | Departments of Surgery, Duke University Medical Center Durham, NC 27710, USA 1Departments of Immunology, Duke University Medical Center Durham, NC 27710, USA 2Departments of Pediatrics, Duke University Medical Center Durham, NC 27710, USA |
| Abstract: | The transplantation of organs from lower animals such as pigsinto humans is prevented by a severe rejection reaction initiatedby complement fixing xenoreactive natural antibodies. Most anti-pigxenoreactive natural antibodies in humans are thought to recognizeGal |
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