Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones |
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Authors: | Ram Vishnu Ji Farhanullah Tripathi Brajendra K Srivastava Arvind K |
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Affiliation: | Division of Medicinal Chemistry, Central Drug Research Institute, 226001, Lucknow, India. vjiram@yahoo.com |
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Abstract: | A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. |
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