Catecholamine control of enzymes involved in isocitrate oxidation of rat liver mitochondria |
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Authors: | V I Kulinsky L V Trufanova A E Medvedev |
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Affiliation: | Department of Biochemistry of Krasnoyarsk Medical Institute, 660022 Krasnoyarsk, USSR |
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Abstract: | Treatment of rats or liver homogenates with catecholamines (isoproterenol or noradrenaline) increased activities of both NAD+ -dependent isocitrate dehydrogenase and NAD(P)+-transhydrogenase (in the direction of hydrogen transfer NADPH----NAD+) with no change in NADP+ -dependent isocitrate dehydrogenase. These effects were realized via beta-adrenoceptors. Cyclic AMP mimicked the catecholamine action on incubation with liver homogenate. The effects of catecholamines and cyclic AMP were not additive. |
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Keywords: | Catecholamine Adrenoceptor Cyclic AMP Mitochondria |
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