Fc receptor gene translocation in a t(1;19) pre-B ALL cell line |
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| Authors: | Lorna M Webber O Margaret Garson Bruce Tate I F C McKenzie P Mark Hogarth |
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| Institution: | (1) Department of Cytogenetics and Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia;(2) Research Centre for Cancer Transplantation, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia;(3) Department of Cytogenetics, St. Vincent's Hospital, 3065 Fitzroy, Victoria, Australia |
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| Abstract: | We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1;19)(g23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene. |
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