Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus: A systematic review with an indirect comparison meta-analysis |
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| Authors: | Yakai Xin Yu Guo Yanle Li Yujin Ma Liping Li Hongwei Jiang |
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| Affiliation: | 1. Department of Endocrinology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China;2. Clinical Medicine Research Center of Endocrine and Metabolic Disease of Luoyang, Luoyang 471003, China;3. Academician Workstation for Diabetic Kidney Disease Research of Henan Province, Luoyang 471003, China;4. Medical College of Henan University of Science and Technology, Luoyang 471003, China |
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| Abstract: | To describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). PubMed, EMBASE, and CENTRAL were searched for randomized controlled trials of SGLT2 inhibitors in patients with T2DM up to Aug 10, 2017, without language or date restrictions. Thirty-one studies totaling 13,650 patients were included. SGLT2 inhibitors significantly decreased SUA levels compared with placebo, canagliflozin WMD –37.02?μmol/L, 95% CI [–38.41, –35.63], dapagliflozin WMD –38.05?μmol/L, 95% CI [–44.47, –31.62], empagliflozin WMD –42.07?μmol/L, 95% CI [–46.27, –37.86]. The drug class effect of SUA reduction suggesting SGLT2 inhibitors might be beneficial for diabetic patients with hyperuricemia. |
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| Keywords: | SGLT2 sodium-glucose co-transporter 2 RCTs randomized controlled trials CKD chronic kidney disease N number of patients CANA canagliflozin DAPA dapagliflozin EMPA empagliflozin PLA placebo Meta-analysis Serum uric acid SGLT2 inhibitor Type 2 diabetes |
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