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The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers
Authors:Antonio Marzio  Joseph Puccini  Youngho Kwon  Natalia K. Maverakis  Arnaldo Arbini  Patrick Sung  Dafna Bar-Sagi  Michele Pagano
Affiliation:1. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA;2. Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA;3. Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX 78229, USA;4. Department of Pathology, New York University School of Medicine, New York, NY 10016, USA;5. Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
Abstract:
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  • Keywords:EMI1  RAD51  HRR  ubiquitin  DNA damage  proteolysis  PARPi resistance  breast cancer  CHK1  BRCA1
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